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Sandeepchowdary Bala

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Articles

A penicillin-binding protein inhibitor series to target drug-resistant Neisseria gonorrhoeae

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By Tsuyoshi Uehara, Brittany Miller, Lindsay M. Avery, Steven Boyd, Mitchell Edwards, Susan Hart, Nathan J. Line, Cullen L. Myers, Annie Stevenson, Kyoko Uehara, Fan Yi, Bibo Wang, Zhenwu Liu, Mingyue Wang, Zhichao Zhao, Haiyan Zhao, Caleb Stratton, Christopher Davies, Rok Tkavc, Ann E. Jerse, Christopher Burns, Denis Daigle, Stephen Condon, Allison L. Zulli, Cassandra L. Chatwin, Guo-Hua Chu, Anthony S. Drager, Gopinath Rongala, Xinming Zhou, Sandeepchowdary Bala, Daniel C. Pevear
| Nature Verified
Abstract Emerging multidrug-resistant Neisseria gonorrhoeae strains possessing altered penA alleles (encoding penicillin-binding protein 2, PBP2) threaten the utility of ceftriaxone, the last remaining outpatient antibiotic for gonorrhoea treatment, posing a global health emergency. Here we report a benzoxaborinine-based penicillin-binding protein inhibitor series (boro-PBPi) developed to address penA-mediated ceftriaxone resistance.
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