Calum A. MacRae on Muck Rack

Calum A. MacRae

United Kingdom
As seen in: S&P Global, Nature, PLOS ONE, GlobalData, eLife, Future Medicine, Just Style, Just-Auto
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Articles

A pilot study in the swine model of lethal cyanide intoxication indicates efficacy of a platinum-methionine complex countermeasure

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By Tara B. Hendry-Hofer, Anjali K. Nath, Shuning Zheng, Brian Logue, Calum A. MacRae, Randall T. Peterson, Gregory T. Knipp, Vikhyat Bebarta, Vallabh Suresh, Matthew M. Behymer, Naoaki Fujii, Ari S. Arzumanian, Vincent Jo Davisson
| Nature Verified
Abstract Cyanide presents a chemical security threat because of its wide availability, due to industrial uses, and significant toxicity. Platinum-thioether complexes are a recent addition to candidate antidotes, showing efficacy in mouse models of hydrogen cyanide inhalation and reversing toxicity measures in rabbits.
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Creating an atlas of variant effects to resolve variants of uncertain significance and guide cardiovascular medicine - Nature Reviews Cardiology

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By Yuta Yamamoto, Qianru Wang, Megan Lancaster, Calum A. MacRae, Euan A. Ashley
| Nature Verified
Abstract Cardiovascular diseases are leading global causes of death and disability, often presenting as interrelated phenotypes of atherosclerotic vascular disease, heart failure and arrhythmias. Cardiovascular diseases arise from interactions between environmental factors and predisposing genotypes and include common Mendelian lipid disorders, cardiomyopathies and arrhythmia syndromes.
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Artificial intelligence-enabled prediction of chemotherapy-induced cardiotoxicity from baseline electrocardiograms - Nature Communications

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By Shinichi Goto, Calum A. MacRae
| Nature Verified
Abstract Anthracyclines can cause cancer therapy-related cardiac dysfunction (CTRCD) that adversely affects prognosis. Despite guideline recommendations, only half of the patients undergo surveillance echocardiograms. An AI model detecting reduced left ventricular ejection fraction from 12-lead electrocardiograms (ECG) (AI-EF model) suggests ECG features reflect left ventricular pathophysiology.
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