Calvine Lai

1 Introduction Sulfilimines, the aza-analogs of sulfoxides, have recently attracted considerable attention [1, 2], primarily as potential bioisosteres of sulfoxides in medicinal chemistry [3]. In particular, Ellman and Gnamm demonstrated that many sulfilimines are chemically and configurationally stable under physiologically relevant conditions, suggesting their incorporation into drug-like molecules [4].

1 Introduction Sulfilimines, the aza-analogs of sulfoxides, have recently attracted considerable attention [1, 2], primarily as potential bioisosteres of sulfoxides in medicinal chemistry [3]. In particular, Ellman and Gnamm demonstrated that many sulfilimines are chemically and configurationally stable under physiologically relevant conditions, suggesting their incorporation into drug-like molecules [4].