Camaron R. Hole

Introduction Cryptococcus neoformans is a globally distributed, encapsulated fungal pathogen that causes life-threatening pneumonia and meningoencephalitis, particularly in immunocompromised individuals. The most common risk group comprises people with impaired CD4+ T cell function, such as those with advanced HIV infection, where cryptococcal meningitis accounts for an estimated 19% of all AIDS-related deaths globally (1, 2).

Fungal and Parasitic Infections | Spotlight Lucy X. Li, Camaron R. Hole, Javier Rangel-Moreno, Shabaana A. Khader, Tamara L. Doering Liise-anne Pirofski, Editor DOI: 10.1128/IAI.00288-20 ABSTRACT Cryptococcus neoformans is a fungal pathogen that kills almost 200,000 people each year and is distinguished by abundant and unique surface glycan structures that are rich in xylose. A mutant strain of C.

Research Article | Host-Microbe Biology Camaron R. Hole, Woei C. Lam, Rajendra Upadhya, Jennifer K. Lodge J. Andrew Alspaugh, Editor DOI: 10.1128/mBio.03373-19 ABSTRACT Cryptococcus neoformans infections are significant causes of morbidity and mortality among AIDS patients and the third most common invasive fungal infection in organ transplant recipients. One of the main interfaces between the fungus and the host is the fungal cell wall.