Cami Rice

1 INTRODUCTION Mitochondrial dysfunction and aberrant cellular metabolism have emerged as critical drivers of many disease processes in humans, including cancer, diabetes, and fibrosis of the lungs and other organs (Alcalá et al., 2017; Loomba et al., 2021; Watanabe et al., 2008). Under homeostatic conditions, cellular energy requirements are largely met by mitochondrial respiration driven by the tricarboxylic acid (TCA) cycle.