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Camille Cushman on Muck Rack

Camille Cushman

New York
As seen in: Nature
NYC ||| @DOPEROOTS @NESTHQ @insomniacdotcom @TheOdyssey ||| Writer / Publicist - Music submissions: camicush@gmail.com

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Articles

PRMT5 inhibition disrupts detained intron splicing and impairs ATR signaling with increased DNA damage

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By Camille Cushman, Colin Fowler, Chiara Mazziotta, Mona Ahmed, Ziad Bakouny, João Paulo, Jacqueline A. Lees, James A. DeCaprio, Jingwei Cheng, Hembly G. Rivas
| Nature Verified
Abstract PRMT5 catalyzes symmetric dimethyl arginine on numerous proteins, with PRMT5 inhibitors (PRMT5i) inducing anti-proliferative effects in preclinical studies. Several models have been proposed to explain sensitivity to PRMT5i including through p53 activation and DNA damage response (DDR) regulation. Here, we interrogate the mechanisms of PRMT5i sensitivity in Merkel cell carcinoma, a neuroendocrine skin cancer sensitive to p53 activation.
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