Camille Daigle

Abstract Background: Cardiovascular diseases (CVDs) remain the leading cause of mortality worldwide, with exercise emerging as a potential non-pharmacological strategy to reduce adverse outcomes. Prior studies examining macrophage responses to exercise primarily focused on recruited C-C motif chemokine receptor 2 (CCR2+) monocytes and macrophages in blood, adipose tissue, and skeletal muscle, but the physiological role of macrophages within the heart remains poorly defined.