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Canchai Yang on Muck Rack

Canchai Yang

As seen in: PLOS, BioRxiv, The Journal of Immunology
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Articles

The membrane-associated ubiquitin ligase MARCHF8 promotes cancer immune evasion by degrading MHC class I proteins

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By Mohamed Khalil, Jie Wang, Canchai Yang, Lexi Vu
| BioRxiv
Abstract The loss of major histocompatibility complex class I (MHC-I) molecules has been proposed as a mechanism by which cancer cells evade tumor-specific T cells in immune checkpoint inhibitor (ICI)-refractory patients. Nevertheless, the mechanism by which cancer cells downregulate MHC-I is poorly understood.
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The membrane-associated ubiquitin ligase MARCHF8 stabilizes the human papillomavirus oncoprotein E7 by degrading CUL1 and UBE2L3 in head and neck cancer

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By Mohamed Khalil, Canchai Yang, Lexi Vu, Smriti Chadha
| BioRxiv
Abstract The human papillomavirus (HPV) oncoprotein E7 is a relatively short-lived protein required for HPV-driven cancer development and maintenance. E7 is degraded through ubiquitination mediated by cullin 1 (CUL1) and the ubiquitin-conjugating enzyme E2 L3 (UBE2L3). However, E7 proteins are maintained at high levels in most HPV-positive cancer cells.
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HPV upregulates MARCHF8 ubiquitin ligase and inhibits apoptosis by degrading the death receptors in head and neck cancer

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By Mohamed Khalil, East Lansing, Canchai Yang, El-Buhouth St, PLOS Pathogens
| PLOS
Loading metrics Open Access Peer-reviewed Research Article ? This is an uncorrected proof. Abstract The membrane-associated RING-CH-type finger ubiquitin ligase MARCHF8 is a human homolog of the viral ubiquitin ligases Kaposi’s sarcoma herpesvirus K3 and K5 that promote host immune evasion. Previous studies have shown that MARCHF8 ubiquitinates several immune receptors, such as the major histocompatibility complex II and CD86.
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