Candelaria Mares Ahlers on Muck Rack

Candelaria Mares Ahlers

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Endogenous p21 levels protect genomic stability by suppressing both excess and restrained nascent DNA syntheses

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By Nicolás L. Calzetta, Sabrina F. Mansilla, Candelaria Mares Ahlers, Agostina P. Bertolin
| Science Magazine
Abstract The rate of DNA synthesis is crucial for full DNA duplication. We report a key role of p21 in controlling this rate. During normal replication, p21 promotes nascent DNA synthesis alongside the DNA polymerase iota (Pol ι)/p53 complex. When p21 is down-regulated but detectable, nascent DNA tracks are longer and discontinuous and rely on primase and DNA polymerase (PrimPol). With the complete elimination of p21, nascent DNA tracks become shorter and continuous and depend on Pol kappa (κ).
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