Candice Baker

Abstract Model organisms have provided critical insights into the basic biology of metabolic disorders, however, one of the greatest limitations to translation has been the absence of the genetic heterogeneity that is characteristic of human populations.

Are you relying on exclamation marks? Padding your language with phrases like “just,” “actually,” or “I think”? Or peppering emails with smiles or emojis? All these are signs of ‘her-alysis’—a phenomenon where women change their workplace behaviours to appear more compliant, humble, or likeable. A recent study by caba reported that over three-quarters of women regularly rewrite their emails out of fear of getting a negative reaction.

Abstract Inflammation and tissue fibrosis co-exist and are causally linked to organ dysfunction1,2. However, the molecular mechanisms driving immune–fibroblast cell communication in human cardiac disease remain unexplored and there are at present no approved treatments that directly target cardiac fibrosis3,4. Here we performed multiomic single-cell gene expression, epitope mapping and chromatin accessibility profiling in 45 healthy donor, acutely infarcted and chronically failing human hearts.