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Canqiang Xu on Muck Rack

Canqiang Xu

As seen in: Nature
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Articles

Inconsistent prediction capability of ImmuneCells.Sig across different RNA-seq datasets

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By Xu Xiao, Canqiang Xu, Wenxian Yang, Rongshan Yu
| Nature Verified
Arising from D. Xiong et al. Nature Communications https://doi.org/10.1038/s41467-020-18546-x (2020) In Xiong et al.1, the ImmuneCells.Sig was identified as a gene expression signature to predict response to immune checkpoint therapy (ICT) from two immune cell subpopulations that are highly enriched in tumors not responding to ICT.
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Ratio of the interferon-γ signature to the immunosuppression signature predicts anti-PD-1 therapy response in melanoma

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By Wenxian Yang, Zhihong Chi, Chuanliang Cui, Canqiang Xu
| Nature Verified
Abstract Immune checkpoint inhibitor (ICI) treatments produce clinical benefit in many patients. However, better pretreatment predictive biomarkers for ICI are still needed to help match individual patients to the treatment most likely to be of benefit. Existing gene expression profiling (GEP)-based biomarkers for ICI are primarily focused on measuring a T cell-inflamed tumor microenvironment that contributes positively to the response to ICI.
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