Cardiometabolic Programme-NIHR UCLH

Original Investigation Effect of a Diagnostic Strategy Using an Elevated and Age-Adjusted D-Dimer Threshold on VTEs in Suspected PE Yonathan Freund, MD, PhD; Anthony Chauvin, MD, PhD; Sonia Jimenez, MD; Anne-Laure Philippon, MD; Sonja Curac, MD; Florent Fémy, MD; Judith Gorlicki, MD; Tahar Chouihed, MD, PhD; Hélène Goulet, MD; Emmanuel Montassier, MD, PhD; Margaux Dumont, MD; Laura Lozano Polo, MD; Pierrick Le Borgne, MD; Mehdi Khellaf, MD, PhD; Donia Bouzid, MD; Pierre-Alexis Raynal, MD;...

suggest that thrombosis with thrombocytopenia syndrome (TTS) can occur after the second dose of the ChAdOx1 nCoV-19 vaccine (AZD1222). We feel it is necessary to distinguish TTS, which can have a number of causes, from vaccine-induced immune thrombocytopenia and thrombosis (VITT), which has a very specific immune pathophysiology ( Prakash Bhuyan and colleaguesappendix).