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Cario W. S. Lo on Muck Rack

Cario W. S. Lo

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Articles

Mapping glioblastoma’s isoform diversity using long-read single-cell analysis

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By Annie Chu, Lun Lee Verified, Dingyuan Wang, Lai-Fung Li, Aya El Helali, Brian Chung, Wenshu Tang, Cario W. S. Lo, Gilberto K. K. Leung
| Nature Verified
Abstract Glioblastoma is a highly aggressive brain tumor with poor prognosis, partly driven by extensive intratumoral heterogeneity and widespread dysregulation of RNA splicing. Alternative splicing shapes cellular identity and function and contributes to tumor progression and treatment resistance. While single-cell RNA sequencing has revealed diverse cellular states within glioblastoma, conventional short-read approaches cannot resolve full-length isoforms.
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