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Carlos Alfaro Quinde on Muck Rack

Carlos Alfaro Quinde

As seen in: BioRxiv
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Articles

Stochastic Modeling of Hematopoietic Stem Cell Dynamics

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By Carlos Alfaro Quinde, Paula Vasquez, Katie Kathrein, Katerina E Krstanovic
| BioRxiv
Abstract The study of hematopoietic stem cell (HSCs) maintenance and differentiation to supply the hematopoietic system presents unique challenges, given the complex regulation of the process and the difficulty in observing cellular interactions in the stem cell niche.
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Loss of Ing4 enhances hematopoietic regeneration in multipotent progenitor cells

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By Georgina A Anderson, Marco Hernandex, Carlos Alfaro Quinde, Zanshé Thompson
| BioRxiv
Abstract Despite its critical role in survival, many aspects of hematopoiesis remain unresolved. In the classical model of the hematopoietic program, quiescent hematopoietic stem cells (HSCs) sit at the top of the hematopoietic hierarchy, with the ability to self-renew and differentiate as needed. HSCs give rise to more proliferative progenitor cells, which possess multipotent potential, but have largely or completely lost self-renewal capabilities.
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