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Di Giammartino D.C. Nishida K. Manley J.L. Mechanisms and consequences of alternative polyadenylation. Mol. Cell. 2011; 43: 853-866 Alternative polyadenylation of mRNA precursors. Nat. Rev. Mol. Cell Biol. 2017; 18: 18-30 Ending the message: poly(A) signals then and now. Genes Dev. 2011; 25: 1770-1782 Alternative cleavage and polyadenylation in health and disease. Nat. Rev. Genet. 2019; 20: 599-614 Tian B. Hu J. Zhang H. Lutz C.S. A large-scale analysis of mRNA polyadenylation of human and mouse genes.
Abstract Recent advancements in functional genomics have provided an unprecedented ability to measure diverse molecular modalities, but learning causal regulatory relationships from observational data remains challenging. Here, we leverage pooled genetic screens and single cell sequencing (i.e. Perturb-seq) to systematically identify the targets of signaling regulators in diverse biological contexts.
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