Carolina Mendonça Gorgulho on Muck Rack

Carolina Mendonça Gorgulho

As seen in: Color Research & Application
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Mechanisms involved in the cytotoxic action of Brazilian propolis and caffeic acid against HEp-2 cells and modulation of P-glycoprotein activity

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By Lívia M. Silva, Yahima Frión-Herrera, Ariane R. Bartolomeu, Carolina Mendonça Gorgulho, José M. Sforcin
| Color Research & Application
Propolis exerted a cytotoxic effect on HEp-2 cells, whereas isolated compounds had no effect on cell viability. Higher concentrations were tested and Caf induced late apoptosis or necrosis in HEp-2 cells, while propolis induced apoptosis, both probably due to ROS generation. P53 expression was downregulated by propolis but not by Caf. CASPASE-3 expression was correlated with induction of both early and late apoptosis, with both propolis and Caf alone upregulating its expression.
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