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Articles

Focal astrocyte loss reveals nuclear translocation during lesion repopulation

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By Marina Herwerth, Matthias T. Wyss, Nicola B. Schmid, Anna Lasne, Jacqueline Condrau, Luca Ravotto, Andres Kaech, Gustav Bredell, Carolina Thomas, Rachel Kim, Petra Kukanja, Christine Stadelmann, Thomas Misgeld, Jeffrey Bennett, Sebastian Jessberger, Aiman S. Saab, Shane A. Liddelow, Bruno Weber, Vladyslav L. Korobeynyk
| Nature Verified
Abstract Astrocyte loss occurs in various neurological conditions and can disrupt local tissue homeostasis. While astrocytes surrounding border-forming lesions adopt reactive states without restoring astrocyte networks, how astrocytes respond to spatially confined astrocyte loss remains poorly understood.
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Proteomic and transcriptomic profiling of brainstem, cerebellum and olfactory tissues in early- and late-phase COVID-19 - Nature Neuroscience

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By Josefine Radke, Jenny Meinhardt, Tom Aschman, Sören Lukassen, Ekaterina Friebel, Naveed Ishaque, Jonas Franz, Carolina Thomas, Dirk Reinhold, Sefer Elezkurtaj, Florian Kurth, Marcel A. Müller, Nils C. Gassen, Julia Melchert, Camila Fernandez-Zapata, Chotima Böttcher, Elke Krüger, Markus Landthaler, Emanuel Wyler, Victor Max Corman, Christine Stadelmann, Markus Ralser, Frank L. Heppner, Michael Mülleder, Christian Conrad
| Nature Verified
Abstract Neurological symptoms, including cognitive impairment and fatigue, can occur in both the acute infection phase of coronavirus disease 2019 (COVID-19) and at later stages, yet the mechanisms that contribute to this remain unclear. Here we profiled single-nucleus transcriptomes and proteomes of brainstem tissue from deceased individuals at various stages of COVID-19. We detected an inflammatory type I interferon response in acute COVID-19 cases, which resolves in the late disease phase.
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Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19 - Nature Neuroscience

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By Josefine Radke, Jonas Franz, Carolina Thomas, Julia Schneider, Robert Lorenz Chua, Roland Eils, Björn Tampe, Franziska Scheibe, Britta Siegmund, Christine Stadelmann, Victor Max Corman
| Nature Verified
Study design Thirty-three deceased individuals with COVID-19 either confirmed by PCR for SARS-CoV-2 (n = 31 of 33) or with clinical features highly suggestive of COVID-19 (n = 2 of 33) were included (Supplementary Table 1). Individuals were not preselected with regard to their clinical symptoms.
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