Caroline Shi-Yan Foo on Muck Rack

Caroline Shi-Yan Foo

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Optimized Background Regimen for Treatment of Active Tuberculosis with the Next-Generation Benzothiazinone Macozinone (PBTZ169)

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By Andréanne Lupien, Anthony Vocat, Caroline Shi-Yan Foo, Emilyne Blattes
| asm.org
ABSTRACTThe efficacy of the standardized four-drug regimen (comprising isoniazid, rifampin, pyrazinamide, and ethambutol) for the treatment of tuberculosis (TB) is menaced by the emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains of Mycobacterium tuberculosis. Intensive efforts have been made to develop new antibiotics or to repurpose old drugs, and several of these are currently being evaluated in clinical trials for their antitubercular activity.
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