Caterina Sbarigia

In real-world setting, 74% of patients with bowel disorders associated with chronic diarrhea (irritable bowel syndrome diarrhea predominant and functional diarrhea) reported a clinical improvement with ondansetron; A low dose ondansetron (median [IQR] 8 mg [8]) may be effective in patients with chronic diarrhea also in the long-term; Treatment with ondansetron is associated with few minor side effects.

Approximately one in three outpatients with Rome IV functional dyspepsia consume opioids. Opioid use is independently associated with older age, depression and/or anxiety, and a chronic pain condition. A combination of opioid cessation and a neuromodulator may have a number needed to treat of 5.7 to achieve an improvement in gastrointestinal symptoms. 1 Introduction The global opioid prescription rate for the management of non-malignant chronic pain has steadily increased over the past decade [1].

1 INTRODUCTION Gastric cancer is the fifth most common neoplasia and the fourth cause of death from neoplastic pathology worldwide.1 Its poor prognosis is mainly due to late diagnosis at an advanced stage of cancer.2 In high-incidence countries for gastric adenocarcinoma (e.g., Japan, China, and Korea), general population screening programmes have been shown to improve survival rates.3 However, in low-incidence countries (e.g., European countries), gastric cancer screening is not recommended.