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The mucus gel layer covering the airway surface periciliary layer (PCL) traps inhaled materials and also acts as a reservoir for water, buffering hydration of the PCL for needed cell-surface lubrication and efficient ciliary beating. Airway surface liquid dehydration and the production of hyperconcentrated mucus lead to airway obstruction and are pathological features of cystic fibrosis (CF), chronic obstructive lung disease (COPD), and asthma.
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