Catherine M. Stein

Abstract Childhood apraxia of speech (CAS) is a severe and rare form of speech sound disorder (SSD). CAS is typically sporadic, but may segregate in families with broader speech and language deficits. We hypothesize that genetic changes may be involved in the etiology of CAS. We conduct whole-genome sequencing in 27 families with CAS, 101 individuals in all. We identify 17 genomic regions including 19 unique copy number variants (CNVs).

Correction to: Nature Immunology https://doi.org/10.1038/s41590-024-01897-8. Published online 12 July 2024. In the version of this article initially published, the name of Chuangqi Wang was misspelled (“Chuanqi”); in Fig. 2a, data were missing in the lower-right plot and in Fig. 2f, the labels, now reading “LTBI” and “RSTR” in top-down fashion, were reversed. The changes have been made in the HTML and PDF versions of the article.

Abstract A subset of individuals exposed to Mycobacterium tuberculosis (Mtb) that we refer to as ‘resisters’ (RSTR) show evidence of IFN-γ− T cell responses to Mtb-specific antigens despite serially negative results on clinical testing. Here we found that Mtb-specific T cells in RSTR were clonally expanded, confirming the priming of adaptive immune responses following Mtb exposure.