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Articles by Catherine S. Grasso
Author Correction: PAK4 inhibition improves PD-1 blockade immunotherapy
Correction to: Nature Cancer https://doi.org/10.1038/s43018-019-0003-0, published online 9 December 2019. In the version of the article originally published, the legend of Fig. 5 and corresponding source data file did not clarify that in Fig. 5a the n = 16 mice shown per group were pooled from three independent experiments. Fig.
Conserved Interferon-γ Signaling Drives Clinical Response to Immune Checkpoint Blockade Therapy in Melanoma
Main Text (Cancer Cell 38, 500–515.e1–e3; October 12, 2020) In this article, we report that T cell-induced interferon-γ correlates to response to immune checkpoint blockade therapy in melanoma patients. We would like to provide two additional supplemental tables. Table S1 details unidentifiable demographic information of patients to facilitate the re-analysis of the data based on specific patient characteristics or subgroups of melanomas.
Conserved Interferon-γ Signaling Drives Clinical Response to Immune Checkpoint Blockade Therapy in Melanoma
Highlights • T cell-induced IFN-γ correlates the best to immune checkpoint blockade (ICB) therapy • Immune signatures increase in on-therapy patients regardless of response to therapy • ICB therapy decreases MYC and WNT signaling in patients with clinical response • IFN-γ exposure of melanoma cells leads to a conserved transcriptome signature Summary We analyze the transcriptome of baseline and on-therapy tumor biopsies from 101 patients with advanced melanoma treated with nivolumab...
Genetic mechanisms of immune evasion in colorectal cancer
Genetic mechanisms of immune evasion in colorectal cancer Catherine S. Grasso, Marios Giannakis, Daniel K. Wells, Tsuyoshi Hamada, Xinmeng Jasmine Mu, Michael Quist, Jonathan A. Nowak, Reiko Nishihara, Zhi Rong Qian, Kentaro Inamura, Teppei Morikawa, Katsuhiko Nosho, Gabriel Abril-Rodriguez, Charles Connolly, Helena Escuin-Ordinas, Milan S. Geybels, William M. Grady, Li Hsu, Siwen Hu-Lieskovan, Jeroen R. Huyghe, Yeon Joo Kim, Paige E. Krystofinski, Mark DM Leiserson, Dennis J. Montoya, Brian B.
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