Cátia Gomes

Highlights • hPSC-derived reactive astrocytes exhibit a predominantly inflammatory phenotype • Reactive astrocytes promote neurodegenerative features in multiple types of neurons • Patient-derived reactive astrocytes result in more robust disease phenotypes Summary Reactive astrocytes are known to exert detrimental effects upon neurons in several neurodegenerative diseases, yet our understanding of how astrocytes promote neurotoxicity remains incomplete, especially in human systems.