Cavanagh Gohlich on Muck Rack

Cavanagh Gohlich

As seen in: Nature
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Articles

Spatial proteomic analysis in human Alzheimer’s disease brains enables identification of microenvironment-dependent microglial cell states

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By Paula Sánchez-Molina, Dennis-Dominik Rosmus, Dillon Brownell, Aditya Pratapa, Yaser Peymanfar, Yue Hou, Nadezhda Nikulina, Alina P Bogachuk, Aude Chiot, Peter Wieghofer, Randall L. Woltjer, Fabian N. Svara, Oliver Braubach, Bahareh Ajami, Mert Meral, Cavanagh Gohlich, Ellen Lara Bouchard, Heidrun Kuhrt
| Nature
Abstract Disease-associated microglial states are thought to contribute to Alzheimer’s disease (AD) progression, but characterizing them and their relationships to pathology remains challenging. Here we introduce CODEX-CNS—a multiplexed protein imaging technology with a custom data analysis pipeline for use in human brain samples.
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