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Articles by Ce Luo
Uncovering spatially resolved functional genomics with CRISPR screen sequencing
Results The SPAC-seq workflow begins with transducing a pooled sgRNA (single guide RNA) library into cell types of interest. After fluorescence-based sorting, the perturbed cells are injected into syngeneic mouse models at specific sites or organs.
Uncovering spatially resolved functional genomics with CRISPR screen sequencing
Results The SPAC-seq workflow begins with transducing a pooled sgRNA (single guide RNA) library into cell types of interest. After fluorescence-based sorting, the perturbed cells are injected into syngeneic mouse models at specific sites or organs.
Arid3b suppresses CD8 + T cell infiltration and function in microsatellite-stable colorectal cancer via Runx3
Abstract Microsatellite-stable/proficient mismatch repair (MSS/pMMR) colorectal cancer (CRC) is characterized by a cold tumor microenvironment, with limited CD8⁺ T cell infiltration and poor responsiveness to immune checkpoint inhibitors (ICIs). Here, using an in vivo CRISPR/Cas9 screen in a CMT93 cell-derived murine tumor model, we identify Arid3b as a key negative regulator of CD8⁺ T cell infiltration and antitumor activity.
Integrated computational analysis identifies therapeutic targets with dual action in cancer cells and T cells
1Center for Quantitative Biology, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100084, China 2Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100084, China 3School of Basic Medical Sciences, Tsinghua University, Beijing 100084, China 4Peking University Chengdu Academy for Advanced Interdisciplinary Biotechnologies, Chengdu, Sichuan 610213, China 5Tsinghua-Peking Center for Life Sciences,...
Analysis of Crack‐Tip Field in Orthotropic Compact Tension Shear Specimens: The Role of Elastic Mode Mixity and T‐Stress
References 1, , , et al., “Exploring the Influence of Specimen Types on the Intralaminar Fracture Behavior of Fiber-Reinforced Polymer Matrix Composites,” Theoretical and Applied Fracture Mechanics 134 (2024): 104684. 2, , , et al., “Analysis of Compact Tension Specimens With Deflected Cracks for Orthotropic Materials,” Theoretical and Applied Fracture Mechanics 134 (2024): 104699.
GRB7 Plays a Vital Role in Promoting the Progression and Mediating Immune Evasion of Ovarian Cancer
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Tumor aerobic glycolysis confers immune evasion through modulating sensitivity to T cell-mediated bystander killing via TNF-α
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