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CeAnn Romanaggi on Muck Rack

CeAnn Romanaggi

As seen in: BioRxiv
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Articles

A Nanobody Interaction with SARS-CoV-2 Spike Allows the Versatile Targeting of Lentivirus Vectors

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By Ayna Alfadhli, Timothy A. Bates, Fikadu Tafesse, CeAnn Romanaggi
| BioRxiv
Abstract While investigating methods to target gene delivery vectors to specific cell types, we examined the potential of using a nanobody against the SARS-CoV-2 Spike protein receptor binding domain to direct lentivirus infection of Spike-expressing cells. Using three different approaches, we found that lentiviruses with surface-exposed nanobody domains selectively infect Spike-expressing cells.
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