Cecily C Midkiff

Loading metrics Open Access Peer-reviewed Research Article ? This is an uncorrected proof. Citation: Wallis ZK, Midkiff CC, Zhao M, Autissier P, Kim SO, Amadeck AQ, et al. (2025) Resolving inflammation: The impact of antiretroviral therapy on macrophage traffic in and out of the CNS. PLoS Pathog 21(12): e1013180. https://doi.org/10.1371/journal.ppat.1013180 Editor: David T.

Abstract The effect of antiretroviral therapy (ART) and therapy interruption on myeloid cell traffic out of the central nervous system (CNS) with human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) infection are understudied.

Abstract Chimeric antigen receptor (CAR)-T cells have demonstrated clinical potential, but current receptors still need improvements to be successful against chronic HIV infection. In this study, we address some requirements of CAR motifs for strong surface expression of a novel anti-HIV CAR by evaluating important elements in the extracellular, hinge, and transmembrane (TM) domains.