Cédric C Laczny

Abstract Small open reading frames (smORFs), which encode proteins under 100 amino acids, represent an underexplored dimension of the human gut microbiome, despite growing evidence of their essential biological roles. Due to small size and poor annotation, smORFs are typically excluded from metagenomic/metaproteomic analyses.

Abstract The human body hosts trillions of microorganisms throughout many diverse habitats with different physico-chemical characteristics. Among them, the oral cavity and the gut harbour some of the most dense and diverse microbial communities. Although these two sites are physiologically distinct, they are directly connected and can influence each other in several ways.

Methods and analysis The first objective of the study is to define specific gut microbiome-derived molecules in RA and PD, compared with healthy individuals, and relate this information to the immunophenotypes of the individuals. The second objective is to identify and track common and disease-specific molecular signatures to predict the outcome of a gut microbiome-targeted therapeutic intervention, here fasting, on inflammation-driven symptoms in RA and PD.