Cédrine Blavet on Muck Rack

Cédrine Blavet

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Articles

Human adipose stromal cells differentiate towards a tendon phenotype with adapted visco-elastic properties in a 3D-culture system

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By Jonathan Fouchard, Xavier Laffray, Cédrine Blavet, Veronique Bereziat
| biorxiv.org
Abstract Tendon cell differentiation relies on molecular and mechanical parameters that control the expression of tendon-associated transcription factors and extracellular matrix proteins. However, the minimal cues able to initiate tendon differentiation from progenitor cells remains unknown. We analysed the tendon differentiation program in human adipose stromal cells (hASCs) cultured in a minimal 3D-system.
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The tendon differentiation program is activated in human adipose stromal cells embedded in a 3D-collagen matrix

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By Jonathan Fouchard, Xavier Laffray, Cédrine Blavet, Veronique Bereziat
| biorxiv.org
Abstract During development, tendon cell differentiation relies on molecular and mechanical parameters that control the expression of tendon collagen and associated extracellular matrix proteins. However, the minimal cues able to initiate tendon differentiation from progenitor cells remains unknown. We analysed the molecular and mechanical parameters associated with tendon differentiation in human adipose stromal cells (hASCs) in a 3D-culture system.
Open in Who Shared Issue with article?

Human adipose stromal cells differentiate towards a tendon phenotype with extracellular matrix production and adapted visco-elastic properties in a 3D-culture system

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By Jonathan Fouchard, Cédrine Blavet, Xavier Laffray, Veronique Bereziat
| biorxiv.org
Abstract Tendons are composed of type I collagen fibrils and specialized extracellular matrix (ECM) proteins that are hierarchically organized to transmit forces from muscle to bone. Reliable and affordable models of human tendon constructs are requested to serve surgical treatment after tendon injury and in vitro pharmacological testing.
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