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Articles by Celina Eckfeld
Subclonal MECOM rearrangements in myeloid neoplasms: enriched for TP53 mutations and adverse outcome
The 5th edition of World Health Organization Classification of Haematolymphoid Tumours of 2022 (WHO-HAEM5) recognizes MECOM rearrangements (MECOMr) as defining for acute myeloid leukemia (AML) representing a distinct subentity with adverse prognosis [1]. Patients with MECOM-rearranged AML typically present with an aggressive disease course, poor response to standard chemotherapy and poor survival [2, 3].
Identification of invariant chain CD74 as a functional receptor of tissue inhibitor of metalloproteinases-1 (TIMP-1)
Multifunctionality of tissue inhibitor of metalloproteinases-1 (TIMP-1) comprising antiproteolytic as well as cytokinic activity has been attributed to its N-terminal and C-terminal domains, respectively. The molecular basis of the emerging proinflammatory cytokinic activity of TIMP-1 is still not completely understood. The cytokine receptor invariant chain (CD74) is involved in many inflammation-associated diseases and is highly expressed by immune cells.
TIMP1 Triggers Neutrophil Extracellular Trap Formation in Pancreatic Cancer
Molecular Cell Biology Benjamin Schoeps, Celina Eckfeld, Olga Prokopchuk, Jan Böttcher, Daniel Häußler, Katja Steiger, Ihsan Ekin Demir, Percy Knolle, Oliver Soehnlein, Dieter E. Jenne, Chris D. Hermann and Achim Krüger DOI: 10.1158/0008-5472.CAN-20-4125 Published July 2021 This article requires a subscription to view the full text. You may purchase access to this article or login to access your subscription using the links below.
TIMP-1 triggers neutrophil extracellular trap formation in pancreatic cancer
Research Article Benjamin Schoeps, Celina Eckfeld, Olga Prokopchuk, Jan P Böttcher, Daniel Häußler, Katja Steiger, Ihsan Ekin Demir, Percy Knolle, Oliver Soehnlein, Dieter E Jenne, Chris D. Hermann and Achim Krüger DOI: 10.1158/0008-5472.CAN-20-4125 Abstract Tumor-derived protein tissue inhibitor of metalloproteinases-1 (TIMP-1) correlates with poor prognosis in many cancers, including highly lethal pancreatic ductal adenocarcinoma (PDAC).
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