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Keywords diffuse midline glioma spatial multi-omics profiling cancer-immune landscape microglia-cancer interaction IGSF11-VISTA immune checkpoint Introduction Diffuse midline glioma (DMG) is a highly aggressive pediatric brain tumor lacking curative treatments.1,2,3 DMG is commonly characterized by a histone H3 lysine 27-to-methionine (H3K27M) mutation, predominantly the H3.3K27M variant.4 This K27M mutation is often accompanied by mutations in oncogenes and tumor suppressor genes, with TP53...
Abstract Diffuse midline glioma (DMG) is a highly aggressive and untreatable pediatric cancer primarily arising in the pontine brainstem region, necessitating the development of representative models for treatment advance. Here we developed an FGF4-driven human brainstem organoid model, which we used to genetically engineer H3.3K27M-altered DMG.
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