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Céline Charon-Barra on Muck Rack

Céline Charon-Barra

As seen in: Nature, EJSO - European Journal of Surgical Oncology
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Articles

MiT fusions, TSC1–TSC2 divergence, and stem-like programs reveal distinct origins and vulnerabilities in PEComa

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By Justine Gantzer, Xiaofan Lu, Céline Charon-Barra, Charles Vinson, Noëlle Weingertner, Antonin Fattori, Marie-Pierre Chenard, Damien Plassard, François Le Loarer, Maud Toulmonde, Marie Karanian, Mehdi Brahmi, Carine Ngo, Axel Le Cesne, Alice Hervieu, François Bertucci, Thomas Ryckewaert, Philippe Rochaix, Thibaud Valentin, Nicolas Macagno, Florence Duffaud, Matthias Tallegas, Emmanuelle Bompas, Marick Laé, Nathalie Rioux-Leclercq, Jean-Yves Blay, Jean-Emmanuel Kurtz, Gabriel G. Malouf, Serge Vicaire, Lenaïg Mescam-Mancini, Juliette Beaujot, Bruno Chetaille, Isabelle Valo, Flore Delalande, Francisco Llamas-Gutierrez
| Nature Verified
Abstract Perivascular epithelioid cell neoplasms (PEComas) are ultra-rare mesenchymal tumors lacking a molecular classification to guide therapy. Here we perform comprehensive multi-omic profiling of an unselected PEComa cohort. We identify frequent MITF rearrangements involving actin gene partners (ACTA2, ACTG1 and ACTB).
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Prognostic factors and outcomes of adult spermatic cord sarcoma. A study from the French Sarcoma Group

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By Gilles Achard, Céline Charon-Barra, Sébastien Carrère, Sylvie Bonvalot
| EJSO - European Journal of Surgical Oncology Verified
To evaluate the outcomes of adult patients with spermatic cord sarcoma (SCS). All consecutive patients with SCS managed by the French Sarcoma Group from 1980 to 2017 were analysed retrospectively. Multivariate analysis (MVA) was used to identify independent correlates of overall survival (OS), metastasis-free survival (MFS), and local relapse-free survival (LRFS). A total of 224 patients were recorded. The median age was 65.1 years.
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Prognostic value of androgen receptor and FOXA1 co-expression in non-metastatic triple negative breast cancer and correlation with other biomarkers

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By Séverine Guiu, Caroline Mollevi, Céline Charon-Barra, Florence Boissière
| Nature Verified
In luminal androgen receptor (AR) tumours, FOXA1 may direct AR to sites occupied by ER in luminal tumours, thus stimulating proliferation. AR and FOXA1 expression were evaluated by immunohistochemistry in 333 non-metastatic triple-negative breast cancers (TNBC). Positivity threshold was set at ≥ 1% staining. Lymphocytic infiltration, PD-L1expression, PIK3CA mutations, PTEN defects and BRCA1 promoter methylation were assessed.
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