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Targeting rapidly cycling receptors CD2 and CD7 increases nanoparticle delivery to primary CD4 + T cells

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By Paula Cevaal, abdalla Ali, Marcel Doerflinger, Christina Cortez-Jugo, Abigail Tan, Haiyin Liu, Moore Z. Chen, Le Wang, Merle Dayton, Liana Mackiewicz, Stanislav Kan, Matthew Faria, Celine Gubser, Céline Gubser, Rene Lafleur, Robert De Rose, Angus Johnston, Frank Caruso, Michael Roche, Jori Symons, Sharon Lewin
| Nature Verified
Abstract T cells are critically important to many diseases but are traditionally difficult to transfect. We hypothesise that the delivery of therapeutic cargo to T cells can be improved by targeting nanoparticles to surface receptors that undergo rapid receptor-mediated endocytosis.
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