Centro BASAL Ciencia

Dedifferentiation programs are commonly enacted during breast cancer progression to enhance tumor cell fitness. Increased cellular plasticity within the neoplastic compartment of tumors correlates with disease aggressiveness, often culminating in greater resistance to cytotoxic therapies or augmented metastatic potential.

The incorporation of experimental data into the structural modelling of nucleic acids is an increasingly common approach, which helps to scale down the sea of possible structures that computer algorithms can propose (1). Among these experimental techniques, small-angle X-ray scattering (SAXS) is a handy tool for providing insight into the global shape and size of macromolecules in solution (2,3), which can be employed to refine models or to guide molecular dynamics (MD) simulations.