Cerebral Rhythmology APHM

The psychiatric burden observed in drug-resistant epilepsy cannot be explained by chronic disease status alone. PTSD is more prevalent and more severe in drug-resistant epilepsy than in atrial fibrillation or type 1 diabetes. Drug-resistant epilepsy is associated with higher anxiety, depression, dissociation, and emotion regulation deficits. Psychiatric comorbidities strongly contribute to reduced quality of life in drug-resistant epilepsy.

The epileptogenic networks of LGS were widely distributed and often involved bilateral frontal regions, as demonstrated by SEEG analysis. Despite high interindividual variability across seizures, EZN organization was consistent according to seizure type. Only a minority of LGS patients explored by SEEG were ultimately eligible for curative surgery. Quantification of SEEG may assist in guiding individual surgical strategy and radiofrequency thermocoagulation targets in LGS.

Introduction The postictal state is an abnormal brain condition lasting from the end of a seizure until the return to interictal baseline1 and often exceeds ictal duration. Moreover, the impact of the postictal period on patients' lives might surpass that of the seizures themselves. Hence, the postictal state emerges as a potential target for epilepsy therapy.2 However, research on this period is still limited.