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Chaehui Yoon on Muck Rack

Chaehui Yoon

As seen in: Nature
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Articles

Gα12/13 deficiency attenuates obesity-associated adipose tissue inflammation and promotes energy expenditure

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By Yeonho Son, Honghyun Jo, Junhyuck Lee, Seunghyeon Shin, Yejin Moon, Cheoljun Choi, Ja Hyun Koo, Je Kyung Seong, Sik Namgoong, Zachary Gerhart-Hines, Minsoo Noh, Sang Geon Kim, Yun-Hee Lee, Seokyoung Hwang, Chaehui Yoon
| Nature Verified
Abstract G protein–coupled receptor signaling via Gα12/13 regulates diverse physiological processes, but its role in adipose tissue metabolism remains largely unknown. Here, we identify Gα12/13 as inhibitory modulators of β-adrenergic Gαs signaling in adipocytes. Obesity is associated with increased Gα12/13 expression in adipose tissue of mice and humans.
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