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Chaima El Arfani on Muck Rack

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IJMS | Free Full-Text | Metabolic Features of Multiple Myeloma | HTML

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By Kim De Veirman, Ken Maes, Elke De Bruyne, Chaima El Arfani
| MDPI
MM is further characterised by osteolysis, whereby malignant plasma cells activate osteoclast (OC) progenitors and initiate osteoclastic bone resorption. Osteoclast formation is stimulated by the adherence of MM cells in the BM via vascular cell adhesion molecule 1 (VCAM-1) and α4β1 integrin. Together with the receptor activator of nuclear factor κB ligand (RANKL), they belong to the osteoclastogenic factors inducing osteolysis [ 22 23 ].
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