Chaitanya Parikh

1 Introduction Cholangiocarcinoma (CCA) is the second most prevalent type of primary liver cancer, which accounts for roughly 15% liver tumors.[1-3] Currently, surgical resection is the preferred treatment for CCA,[1-3] but most patients are diagnosed at an advanced stage with unresectable disease, due to a lack of tumor markers for early diagnosis.

1 Introduction Cholangiocarcinoma (CCA) is the second most prevalent type of primary liver cancer, which accounts for roughly 15% liver tumors.[1-3] Currently, surgical resection is the preferred treatment for CCA,[1-3] but most patients are diagnosed at an advanced stage with unresectable disease, due to a lack of tumor markers for early diagnosis.

Abstract Naive pluripotent stem cells (nPSC) frequently undergo pathological and not readily reversible loss of DNA methylation marks at imprinted gene loci. This abnormality poses a hurdle for using pluripotent cell lines in biomedical applications and underscores the need to identify the causes of imprint instability in these cells.