Chandresh Nanji Ladva on Muck Rack

Chandresh Nanji Ladva

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Articles

Particulate metal exposures induce plasma metabolome changes in a commuter panel study

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By Rachel Golan, Ben-Gurion, Roby Greenwald, Chandresh Nanji Ladva
| PLOS
HRM detected 10-hr perturbations in 110 features associated with in-vehicle, particulate metal exposures (Al, Pb, and Fe) which reflect changes in arachidonic acid, leukotriene, and tryptophan metabolism. Two-hour changes in proinflammatory biomarkers hs-CRP, IL-6, IL-8, and IL-1β were also associated with 10-hr changes in the plasma metabolome, suggesting diverse amino acid, leukotriene, and antioxidant metabolism effects.
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