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Chang Ying on Muck Rack

Chang Ying

As seen in: Nature
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Articles

Intratumoral bicarbonate functions as an adjuvant to potentiate PD-1 blockade in hepatocellular carcinoma

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By Di Wang, Kai Jin, Chang Ying, Guangqiang Zhang, Jiangtao Li, Lirong Chen, Ming Chao, Xun Hu
| Nature Verified
Abstract AntiPD-1 immunotherapy improves survival in advanced hepatocellular carcinoma (HCC), but responses remain limited by the immunosuppressive, acidic tumor microenvironment (TME). We investigated whether intratumoral alkalization with sodium bicarbonate could enhance PD-1 blockade.
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Alkalization of the intracellular pH reprograms TNF-α signaling from inflammatory NF-κB activation to tumoricidal RIP kinase-dependent necroptosis in cancer cells

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By Di Wang, Xun Hu, Chang Ying, Si-ying Zeng, Cheng-meng Jin, Min-feng Ying
| Nature Verified
Abstract Tumor necrosis factor-alpha (TNF-α) plays paradoxical roles in cancer, promoting tumor survival via NF-κB activation while also inducing necroptotic cell death. Here, we identify the intracellular pH (pHᵢ) as a decisive switch that reprograms TNF-α signaling from a prosurvival inflammatory response toward tumoricidal necroptosis.
Open in Who Shared Issue with article?
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