Changchang Xin on Muck Rack

Changchang Xin

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Articles

Transfer of mitochondrial DNA into the nuclear genome during induced DNA breaks - Nature Communications

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By Jinchun Wu, Yang Liu Verified, Liqiong Ou, Xinyi Liu, Changchang Xin, Ye Tian
| Nature Verified
Abstract Mitochondria serve as the cellular powerhouse, and their distinct DNA makes them a prospective target for gene editing to treat genetic disorders. However, the impact of genome editing on mitochondrial DNA (mtDNA) stability remains a mystery.
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Global detection of DNA repair outcomes induced by CRISPR-Cas9

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By Weiwei Zhang, Mengzhu Liu, Changchang Xin, Jianhang Yin
| biorxiv.org
New Results Mengzhu Liu, Weiwei Zhang, Changchang Xin, Jianhang Yin, Yafang Shang, Chen Ai, Jiaxin Li, Fei-long Meng, View ORCID ProfileJiazhi Hu doi: https://doi.org/10.1101/2021.02.15.431335 Abstract CRISPR-Cas9 generates double-stranded DNA breaks (DSBs) to activate cellular DNA repair pathways for genome editing. The repair of DSBs leads to small insertions or deletions (indels) and other complex byproducts, including large deletions and chromosomal translocations.
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