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Changjiu Tang

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Articles

Identification of a novel variant (c.1‐111A>G) located in GATA‐1 motif of RHCE proximal promoter in two Chinese patients with the rare D‐‐ phenotype

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By Ran Zhang, Jizhi Wen, Shuangshuang Jia, Changjiu Tang
| Wiley Online Library Verified
Background D-- is a rare phenotype lacking the expression of the C, c, E, and e antigens and several high-frequency antigens on the red cells. Anti-Rh17 (Hr0) could be developed in individuals with the D-- phenotype to cause hemolytic transfusion reactions (HTR) and hemolytic disease of the fetus and newborn (HDFN). Nuleotide(s) change of the RHCE gene and RHCE-D-CE hybrid alleles are the common molecular basis of the D-- phenotype.
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