Abstract The current research aimed to analyze the influencing factors for congenital heart disease (CHD) in children based on a case–control study. From January 2020 to January 2022, 60 children with CHD under 6 years of age admitted to the Affiliated Hospital of Southwest Medical University were selected as the research group. Another 60 children matched for age and sex who underwent physical examinations in our hospital without CHD were selected as the control group.