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Diewen Feng

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Articles

Sequencing-based spatial transcriptomics with high sensitivity

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By Renjie Liao, Defeng Fu, Zaoxu Xu, Xiaoran Zhou, Yiling Chen, Xueqi Liu, Jiajun Cheng, Chen Li, Huihua Xia, Gailing Li, Yang Chen, Zihang Huang, Qingbin Chen, Dexia Chen, Shuguang Xuan, Changling Zhang, Yongyi Lu, Hui Wang, Yuanye Bao, Luyang Zhao, Erkai Liu, Gufeng Wang, Diewen Feng, Longchao Chen, Taiqing Feng
| Nature Verified
Abstract The advent of spatial transcriptomics has dramatically expanded our ability to study the vast network of cell-cell interactions at the molecular level in tissue. Among current methods, sequencing-based approaches have great potential in discovery because of their unbiased capture of the whole transcriptome. In the last couple of years, the spatial resolution for the capture addresses has been improved from ~100 μm to <1 μm, well below the size of a mammalian cell.
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