Changying Jing

1 Introduction Aldosterone, produced by zona glomerulosa (zG) cells in the adrenal cortex, is crucial for electrolyte balance and blood volume homeostasis.[1] In primary aldosteronism (PA), a common cause of secondary hypertension, aldosterone is secreted autonomously, leading to excessive production and clinical implications such as resistant hypertension and increased cardiovascular risk.[2, 3] PA affects ≈6% of the general hypertensive population, rising to 10–20% in specialized...