Changying Xue

Abstract As a critical advancement in modern immunization strategies, multivalent vaccines combine multiple antigenic components to seamlessly broaden protection against diverse pathogens within a single dose. During the formulation of aluminum-adjuvanted vaccines, antigen adsorption onto the adjuvant surface serves as a critical determinant of vaccine performance.

1 Introduction Flow-through bioseparation requires materials that combine accessible internal surface area, low-resistance convective pathways, and mechanical stability under repeated processing conditions. Packed beds of polymeric resins remain the industrial benchmark [1], yet their compressibility under pressure and susceptibility to fouling have sustained interest in rigid, open-pore alternatives.

Abstract Therapeutic vaccines containing aluminum adjuvants have been widely used in the treatment of tumors due to their powerful immune-enhancing effects. However, the neurotoxicity of aluminum adjuvants with different physicochemical properties have not been completely elucidated. In this study, a library of engineered aluminum oxyhydroxide (EAOs) and aluminum hydroxyphosphate (EAHPs) nanoparticles was synthesized to determine their neurotoxicity in vitro.