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Chaofeng Zhang on Muck Rack

Chaofeng Zhang

As seen in: Nature, Wiley Online Library, MDPI, Taylor & Francis Online, Royal Society of Chemistry, Canadian Journal of Infectious Diseases & Medical Microbiology, Chemistry World
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Articles

Ruxolitinib inhibits CaMKII-γ to reverse bortezomib resistance in multiple myeloma

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By Ruqi Liang, Hong liu, Yizhao Chen, Jianru Tian, Chaofeng Zhang, Mingdi Wang, Xushan Zhong
| Nature Verified
Abstract Multiple myeloma (MM) is the second most common hematologic malignancy, with increasing incidence and earlier onset. Despite the therapeutic efficacy of proteasome inhibitors and other strategies, nearly all patients eventually develop resistance, making the discovery of novel drug targets and innovative therapeutic approaches an urgent clinical need.
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Standardization transformation of C-lignin to catechol and propylene - Nature Communications

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By Xiaojun Shen, Jialong Wen, Guangjin Hou, Yuhe Liao, Chaofeng Zhang
| Nature Verified
Abstract Standardization transformation of lignin to high-value-added chemicals requires precise control of the reaction process based on the elaborate catalytic strategy design and lignin structure optimization. Here we report the selective and efficient preparation of bio-catechol and bio-propylene from the ideal C-lignin via a one-pot hydrogenolysis-dealkylation cascade catalysis.
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Radical-Friedel-Crafts Benzylation of Arenes over the Metallic-Basic Bifunctional MoO2 Surface

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By Chaofeng Zhang, Zhuo Li, Kaiyi Su, Bo Jiang, Tingwei Zhang
| Royal Society of Chemistry Verified
Radical-Friedel-Crafts Benzylation of Arenes over the Metallic-Basic Bifunctional MoO2 Surface Selective ether bond activation is essential in organic synthesis and natural polymer depolymerization. Herein, we reported that the MoO2 with negligible acidity but metallic-basic bifunctional characterization could efficiently catalyze the benzylation of arenes with benzyl ethers as the benzylation reagent via a Radical-Friedel-Crafts mechanism.
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