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Chaoying Long on Muck Rack

Chaoying Long

As seen in: Nature
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Articles

Long-read proteogenomic atlas of human neuronal differentiation reveals isoform diversity informing neurodevelopmental risk mechanisms

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By Nuo Xu, Elizabeth Radley, Ai Tian, Jimmy Ly, Hua Luo, Maria Fafouti, Fatima naimi, Yun Li Verified, John Calarco, Brett Trost, Julien Muffat, Hyun Lee, Craig A. Smibert, Shreejoy J. Tripathy, Katherine M. Rynard, Maahil Arshad, Chaoying Long, Ellie Hogan, Melanie Davie, Howard D. Lipshitz
| Nature Verified
Abstract RNA splicing shapes neuronal identity and disease risk, yet current maps lack the developmental resolution and depth to resolve this complexity. Here, we integrate deep long-read RNA sequencing and proteomics in induced pluripotent stem cell-derived cortical neurons to generate a high-resolution proteogenomic atlas of human neuron development.
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