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Leflunomide alleviates obesity via activation of the TAK1‐AMPK pathway and induction of lipophagy
REFERENCES 1, , , et al. Signaling pathways in obesity: mechanisms and therapeutic interventions. Signal Transduct Target Ther. 2022; 7:298. 2, , . Targeting autophagy in obesity: from pathophysiology to management. Nat Rev Endocrinol. 2018; 14: 356-376. 3, , , et al. Obesity in COVID-19 era, implications for mechanisms, comorbidities, and prognosis: a review and meta-analysis. Int J Obes (Lond). 2021; 45: 998-1016. 4, , . Global pandemics interconnected - obesity, impaired metabolic health and COVID-19.
Deregulation of the miR-16-KRAS axis promotes colorectal cancer
We first determined the expression patterns of the KRAS protein in human CRC tissues. We found that the KRAS protein expression levels were significantly higher in the CRC tissues than in the normal adjacent tissue (NAT) samples (Fig. 1A and B). The mean expression levels of KRAS protein in the CRC and NAT samples are shown in Supplementary Fig. 1A.
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