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Neoadjuvant Fc-enhanced anti-CTLA-4 targets Tregs to augment androgen deprivation in high-risk prostate cancer: A randomized phase I trial

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By Casey Ager, Aleksandar Obradovic, Patrick McCann, Matthew G. Chaimowitz, Alexander Wang, Neha Shaikh, Parin N Shah, Samuel S. Pan, Caroline J. Laplaca, Renu K. Virk, Jessica Hill, Collin Jugler, Grace DeFranco, Nilika Bhattacharya, Kade R. Copple, PHUONG DUNG NGUYEN Verified, Phương Nguyên, Howard I. Scher, Christopher Anderson, James McKiernan, Catherine S. Spina, Mark Stein, Karie Runcie, Charles Drake, Andrea Califano, Matthew Dallos, Guarionex Joel DeCastro
| Cell Reports Medicine Verified
Keywords regulatory T cells CTLA-4 prostate cancer neoadjuvant immunotherapy CyTOF single-cell RNA sequencing tumor-associated macrophages dendritic cells Introduction To date, immune checkpoint blockade immunotherapy (ICB) has proven largely ineffective for patients with prostate cancer (PCa).1,2,3 Agents targeting the PD-1/PD-L1 pathway alone or in combination with androgen receptor inhibitors,4,5,6 chemotherapy,7 or PARP inhibition8 have failed in phase III trials.9 Similarly, CTLA-4...
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By James Stewart, Joséphine Hull, Charles Drake, Peggy Dow
| JustWatch
Where to watch Watch for free Synopsis Trailers Similar titles Subtitle languages English Video technology Dolby Vision Subtitle languages English Video technology Dolby Vision Video technology Dolby Vision Subtitle languages English Video technology Dolby Vision Video technology Dolby Vision Didn't find what you were looking for? Let us notify you once it becomes available on more services. Something wrong?
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